Rofecoxib

Name: Rofecoxib Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

92 interactions 5 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Pemetrexed Injection Aspirin

4 Contraindicated 60 Major 28 Moderate

All (92) Contraindicated (4) Major (60) Moderate (28)

Moderate

Rofecoxib Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Rofecoxib Levofloxacin Levaquin An increased risk of seizures Details Rofecoxib Levofloxacin Injection Levaquin An increased risk of seizures Details Rofecoxib Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Rofecoxib Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Rofecoxib Nadolol Corgard Reduced antihypertensive effect Details Rofecoxib Nebivolol Bystolic Reduced antihypertensive effect Details Rofecoxib Ofloxacin Floxin® An increased risk of seizures Details Rofecoxib Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Rofecoxib Ofloxacin Otic Floxin® Otic An increased risk of seizures Details Rofecoxib Penbutolol Levatol® Reduced antihypertensive effect Details Rofecoxib Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.