Roflumilast

36 interactions 1 explained in plain English

Also sold as: Daliresp Daliresp® Zoryve

About Roflumilast

Roflumilast is used in people with severe chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways) to reduce the number of episodes or worsening of COPD symptoms. Roflumilast is in a class of medications called phosphodiesterase inhibitors. It works by decreasing swelling in t… Read the full Roflumilast drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Asciminib Clotrimazole Linagliptin Olaparib Estradiol Transdermal Patch Cyclosporine Injection

36 Major

All (36) Major (36)

Major

Roflumilast Asciminib Scemblix Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Azithromycin AzaSite Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Belumosudil Rezurock Explained Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Bicalutamide Casodex Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Atorvastatin Atorvaliq Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Amlodipine Amvaz® Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Brodalumab Injection Siliq Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Clotrimazole Aardora Anti-Fungal Maximum Strength Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Clotrimazole Lozenge Mycelex® Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Clotrimazole Topical Cruex Antifungal Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Clotrimazole Vaginal Gyne-Lotrimin 3® Cream Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Cyclosporine Injection Atopica Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Cyclosporine Ophthalmic Cequa Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Entrectinib Rozlytrek Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Erdafitinib Balversa Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Esketamine Nasal Spray Spravato Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Esomeprazole Nexium Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Esomeprazole Injection Nexium Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Estradiol Delestrogen Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Estradiol Topical Divigel Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Estradiol Transdermal Patch Alora® Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Everolimus Afinitor Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Fostamatinib Tavalisse Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Ibrexafungerp Brexafemme Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Istradefylline Nourianz Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Ketoconazole Topical Extina® Foam Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Lefamulin Xenleta Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Lenacapavir Injection Sunlenca Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Lenacapavir Oral Sunlenca Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Letermovir Injection Prevymis Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Levonorgestrel After banger Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Levonorgestrel Intrauterine System Kyleena Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Linagliptin Tradjenta Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Lumateperone Caplyta Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Lurasidone Latuda Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Roflumilast Olaparib Lynparza Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.