Drug Interaction Report

Rosiglitazone and Abiraterone: Interaction Details

A pharmacist-reviewed analysis of the Rosiglitazone and Abiraterone interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Abiraterone

Abirtega Yonsa Zytiga Zytiga®
+

Rosiglitazone

Avandia®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 45 documented Rosiglitazone interactions, 25 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

Increased rosiglitazone exposure

Interaction Deep Dive

The concomitant use of abiraterone acetate, a strong CYP2C8 inhibitor1, with rosiglitazone, a CYP2C8 substrate, may cause increased rosiglitazone exposure 3. Patients should be monitored closely 1 for blood glucose levels as the coadministration of abiraterone acetate with antidiabetic agents such as rosiglitazone may increase the risk of severe hypoglycemia 2, and changes to diabetes therapy may be needed, especially when abiraterone acetate is started or stopped during treatment with rosiglitazone 3.

Why it happens (mechanism)

Inhibition of CYP2C8-mediated metabolism of rosiglitazone by abiraterone acetate; additive hypoglycemia

Common questions

Can I take Rosiglitazone and Abiraterone together?

Increased rosiglitazone exposure Always confirm with your pharmacist or prescriber before making any change.

How serious is the Rosiglitazone and Abiraterone interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

From our Q&A

Real reader questions about these medications, each personally answered by our pharmacist:

Questions for your pharmacist

  • Does my dose of Rosiglitazone or Abiraterone need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (3)

  1. Product Information: ZYTIGA(R) oral tablets, abiraterone acetate oral tablets. Janssen Biotech Inc (per FDA), Horsham, PA, 2018. DailyMed
  2. Product Information: AKEEGA(TM) oral tablets, niraparib, abiraterone acetate oral tablets. Janssen Biotech, Inc. (per FDA), Horsham, PA, 2023. DailyMed
  3. Product Information: AVANDIA(R) oral tablets, rosiglitazone maleate oral tablets. GlaxoSmithKline (per DailyMed), Research Triangle Park, NC, 2012. DailyMed
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Abiraterone

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All Abiraterone interactions (164) Abiraterone drug information
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Rosiglitazone

Keep reading about Rosiglitazone

All Rosiglitazone interactions (45) Rosiglitazone drug information
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Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Abiraterone + Activated Charcoal Beer Grapefruit Siberian Cocklebur St. John's Wort Wine Acacia Rigidula Adrafinil + 173 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.