Sacubitril

Name: Sacubitril Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

12 interactions 1 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lisinopril Benazepril Captopril Enalapril Fosinopril Moexipril

7 Contraindicated 5 Major

All (12) Contraindicated (7) Major (5)

Contraindicated

Sacubitril Lisinopril Prinivil Explained Increased risk of angioedema Details Sacubitril Benazepril Lotensin Increased risk of angioedema Details Sacubitril Captopril Capoten® Increased risk of angioedema Details Sacubitril Enalapril Epaned Increased risk of angioedema Details Sacubitril Fosinopril Monopril® Increased risk of angioedema Details Sacubitril Moexipril Univasc® Increased risk of angioedema Details Sacubitril Perindopril Aceon Increased risk of angioedema Details

Major

Sacubitril Atogepant Qulipta Increased atogepant exposure Details Sacubitril Azilsartan Edarbi Increased risk of adverse events Details Sacubitril Eprosartan Teveten® Increased risk of adverse events Details Sacubitril Irbesartan Avapro Increased risk of adverse events Details Sacubitril Losartan Arbli Increased risk of adverse events Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.