Salicylic Acid

85 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Pemetrexed Injection Aspirin
4 Contraindicated 53 Major 28 Moderate
All (85) Contraindicated (4) Major (53) Moderate (28)

Contraindicated

Salicylic Acid Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Salicylic Acid Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Salicylic Acid Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Salicylic Acid Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Salicylic Acid Amitriptyline Elavil Explained An increased risk of bleeding Details Salicylic Acid Sertraline Explained An increased risk of bleeding Details Salicylic Acid Apixaban Eliquis Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Salicylic Acid Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Salicylic Acid Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Salicylic Acid Betrixaban Bevyxxa® An increased risk of bleeding Details Salicylic Acid Anagrelide Agrylin An increased risk of bleeding Details Salicylic Acid Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Salicylic Acid Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Salicylic Acid Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Salicylic Acid Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Salicylic Acid Clopidogrel Plavix An increased risk of bleeding Details Salicylic Acid Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Salicylic Acid Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Salicylic Acid Dalteparin Injection Fragmin An increased risk of bleeding Details Salicylic Acid Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Salicylic Acid Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Salicylic Acid Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Salicylic Acid Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Salicylic Acid Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Salicylic Acid Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Salicylic Acid Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Salicylic Acid Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Salicylic Acid Dipyridamole Permole® An increased risk of bleeding Details Salicylic Acid Edoxaban Savaysa Increased risk of bleeding Details Salicylic Acid Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Salicylic Acid Enoxaparin Lovenox An increased risk of bleeding Details Salicylic Acid Enoxaparin Injection Lovenox An increased risk of bleeding Details Salicylic Acid Epoprostenol Flolan An increased risk of bleeding Details Salicylic Acid Etodolac Lodine Increased risk of bleeding Details Salicylic Acid Fenoprofen Fenopron Increased risk of bleeding Details Salicylic Acid Flurbiprofen Ansaid Increased risk of bleeding Details Salicylic Acid Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Salicylic Acid Furosemide Injection Disal An increased risk of salicylate toxicity and reduced diuretic effectiveness and possible nephrotoxicity Details Salicylic Acid Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Salicylic Acid Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.