Salicylic Acid

85 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Pemetrexed Injection Aspirin
4 Contraindicated 53 Major 28 Moderate
All (85) Contraindicated (4) Major (53) Moderate (28)

Major

Salicylic Acid Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Salicylic Acid Iloprost Aurlumyn An increased risk of bleeding Details Salicylic Acid Ketoprofen Actron® Increased risk of bleeding Details Salicylic Acid Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Salicylic Acid Meclofenamate Meclodium® Increased risk of bleeding Details Salicylic Acid Mefenamic Acid Ponstel® Increased risk of bleeding Details Salicylic Acid Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Salicylic Acid Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Salicylic Acid Melphalan Alkeran An increased risk of bleeding Details Salicylic Acid Melphalan Injection Alkeran An increased risk of bleeding Details Salicylic Acid Mesalamine Apriso Increased risk of bleeding Details Salicylic Acid Mesalamine Rectal Canasa Increased risk of bleeding Details Salicylic Acid Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Salicylic Acid Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Salicylic Acid Nabumetone Relafen Increased risk of bleeding Details Salicylic Acid Naproxen Aleve Increased risk of bleeding Details Salicylic Acid Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

Moderate

Salicylic Acid Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salicylic Acid Atenolol Tenormin Explained Reduced antihypertensive effect Details Salicylic Acid Acebutolol Sectral® Reduced antihypertensive effect Details Salicylic Acid Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salicylic Acid Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salicylic Acid Betaxolol Betoptic S Reduced antihypertensive effect Details Salicylic Acid Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Salicylic Acid Bisoprolol Zebeta® Reduced antihypertensive effect Details Salicylic Acid Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salicylic Acid Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Salicylic Acid Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salicylic Acid Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salicylic Acid Esmolol Brevibloc Reduced antihypertensive effect Details Salicylic Acid Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salicylic Acid Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salicylic Acid Labetalol Normodyne® Reduced antihypertensive effect Details Salicylic Acid Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Salicylic Acid Levofloxacin Levaquin An increased risk of seizures Details Salicylic Acid Levofloxacin Injection Levaquin An increased risk of seizures Details Salicylic Acid Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salicylic Acid Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salicylic Acid Nadolol Corgard Reduced antihypertensive effect Details Salicylic Acid Nebivolol Bystolic Reduced antihypertensive effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.