Salmeterol

16 interactions 2 explained in plain English
Also sold as: Serevent
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Nadolol Letermovir Injection Levobunolol Ophthalmic Mitapivat Olodaterol Oral Inhalation Penbutolol
16 Major
All (16) Major (16)

Major

Salmeterol Abametapir Explained Increased exposure of CYP3A4 substrate Details Salmeterol Atenolol Tenormin Explained Reduced efficacy of salmeterol Details Salmeterol Acebutolol Sectral® Reduced efficacy of salmeterol Details Salmeterol Betaxolol Betoptic S Reduced efficacy of salmeterol Details Salmeterol Betaxolol Ophthalmic Betoptic® Reduced efficacy of salmeterol Details Salmeterol Bisoprolol Zebeta® Reduced efficacy of salmeterol Details Salmeterol Esmolol Brevibloc Reduced efficacy of salmeterol Details Salmeterol Ketoconazole Topical Extina® Foam Increased salmeterol exposure and an increased risk of salmeterol-related adverse effects (including cardiovascular adverse effect... Details Salmeterol Labetalol Normodyne® Reduced efficacy of salmeterol Details Salmeterol Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Salmeterol Levobunolol Ophthalmic AKBeta® Reduced efficacy of salmeterol Details Salmeterol Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Salmeterol Nadolol Corgard Reduced efficacy of salmeterol Details Salmeterol Nebivolol Bystolic Reduced efficacy of salmeterol Details Salmeterol Olodaterol Oral Inhalation Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... Details Salmeterol Penbutolol Levatol® Reduced efficacy of salmeterol Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.