Sars-Cov-2 (Covid-19) Vaccine, Mrna (Moderna)

Name: Sars-Cov-2 (Covid-19) Vaccine, Mrna (Moderna) Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

9 interactions 1 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Elivaldogene Autotemcel Injection Ocrelizumab Injection

2 Major 7 Moderate

All (9) Major (2) Moderate (7)

Major

Sars-Cov-2 (Covid-19) Vaccine, Mrna (Moderna) Elivaldogene Autotemcel Injection Skysona Reduced vaccine effectiveness and increased risk of infection Details Sars-Cov-2 (Covid-19) Vaccine, Mrna (Moderna) Ocrelizumab Injection Ocrevus Reduced efficacy of non-live vaccines Details

Moderate

Sars-Cov-2 (Covid-19) Vaccine, Mrna (Moderna) Abatacept Injection Orencia Decreased immune response to COVID-19 vaccine Details Sars-Cov-2 (Covid-19) Vaccine, Mrna (Moderna) Abatacept Orencia Explained Decreased immune response to COVID-19 vaccine Details Sars-Cov-2 (Covid-19) Vaccine, Mrna (Moderna) Baricitinib Olumiant Decreased immune response to COVID-19 vaccine Details Sars-Cov-2 (Covid-19) Vaccine, Mrna (Moderna) Cyclophosphamide Cytoxan® Decreased immune response to COVID-19 vaccine Details Sars-Cov-2 (Covid-19) Vaccine, Mrna (Moderna) Cyclophosphamide Injection Cytoxan® Injection Decreased immune response to COVID-19 vaccine Details Sars-Cov-2 (Covid-19) Vaccine, Mrna (Moderna) Methotrexate Jylamvo Decreased immune response to COVID-19 vaccine Details Sars-Cov-2 (Covid-19) Vaccine, Mrna (Moderna) Methotrexate Injection Abitrexate® Decreased immune response to COVID-19 vaccine Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.