Sebetralstat and Lenacapavir Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Lenacapavir Injection
Sebetralstat
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased sebetralstat exposure and an increased risk sebetralstat-related adverse reaction
Interaction Deep Dive
Coadministration of sebetralstat (CYP3A4 substrate) with moderate CYP3A4 inhibitors may increase sebetralstat exposure, which may increase the risk of sebetralstat adverse reactions. In drug interaction studies, sebetralstat Cmax increased 1.8-fold and AUC(0 to inf) increased 2-fold following concomitant administration with verapamil (a moderate CYP3A4 inhibitor) 240 mg once daily for 6 days. Reduce sebetralstat dosage to 300 mg (one tablet) orally at earliest recognition of an acute hereditary angioedema (HAE) attack. A second dose of 300 mg (one tablet) may be taken at least 3 hours after first dose if response is inadequate or if symptoms worsen or recur1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of sebetralstat
Literature reports
1 report — tap to read
a) In drug interaction studies, sebetralstat Cmax increased 1.8-fold and AUC(0 to inf) increased 2-fold following concomitant administration with verapamil (a moderate CYP3A4 inhibitor) 240 mg once daily for 6 days 1.
Common questions
Can I take Sebetralstat and Lenacapavir Injection together?
Increased sebetralstat exposure and an increased risk sebetralstat-related adverse reaction Always confirm with your pharmacist or prescriber before making any change.
How serious is the Sebetralstat and Lenacapavir Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Sebetralstat or Lenacapavir Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: EKTERLY(R) oral tablets, sebetralstat oral tablets. KalVista Pharmaceuticals, Inc (per manufacturer), Cambridge, MA, 2025. DailyMed
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