Secnidazole

Name: Secnidazole Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

9 interactions

Also sold as: Solosec Solosec®

About Secnidazole

Secnidazole is used to treat bacterial vaginosis (an infection caused by an overgrowth of harmful bacteria in the vagina) in females 12 years of age and older. It is also used to treat trichomoniasis (a sexually transmitted disease that can affect both men and women) in people 12 years of age and older. Secnidazole is… Read the full Secnidazole drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Capecitabine Disulfiram Exenatide Injection Fluorouracil Fluorouracil Injection Fluorouracil Topical

8 Major 1 Moderate

All (9) Major (8) Moderate (1)

Major

Secnidazole Capecitabine Xeloda Increased exposure of 5-fluorouracil Details Secnidazole Disulfiram Antabuse Risk of sudden psychiatric symptoms (eg, delirium, confusion) Details Secnidazole Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Secnidazole Fluorouracil Adrucil Increased exposure of 5-fluorouracil Details Secnidazole Fluorouracil Injection Adrucil Increased exposure of 5-fluorouracil Details Secnidazole Fluorouracil Topical Carac Increased exposure of 5-fluorouracil Details Secnidazole Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Secnidazole Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Secnidazole Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.