Secobarbital
40 interactions 3 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Nalbuphine Injection
Amitriptyline
Medroxyprogesterone
Butorphanol Injection
Butorphanol Nasal Spray
Estradiol Transdermal Patch
Major
Secobarbital Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Secobarbital Amitriptyline Elavil Explained Reduced tricyclic antidepressant exposure and possible additive adverse effects Details Secobarbital Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Secobarbital Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Secobarbital Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Secobarbital Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Secobarbital Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Secobarbital Diazepam Nasal Spray Valtoco An increased risk of CNS and respiratory depression Details Secobarbital Diazepam Rectal Diastat An increased risk of CNS and respiratory depression Details Secobarbital Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Secobarbital Doxycycline Injection Acticlate Reduced doxycycline exposure and reduced efficacy of doxycycline Details Secobarbital Esketamine Nasal Spray Spravato Increased risk of sedation Details Secobarbital Estradiol Delestrogen Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleeding... Details Secobarbital Estradiol Topical Divigel Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleeding... Details Secobarbital Estradiol Transdermal Patch Alora® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleeding... Details Secobarbital Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Secobarbital Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Secobarbital Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Secobarbital Lacosamide Injection Motpoly An increased risk of CNS depression Details Secobarbital Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Secobarbital Levonorgestrel After banger Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleeding... Details Secobarbital Levonorgestrel Intrauterine System Kyleena Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleeding... Details Secobarbital Medroxyprogesterone Amen® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleeding... Details Secobarbital Medroxyprogesterone Injection Depo-Provera Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleeding... Details Secobarbital Metoclopramide Injection Gimoti Increased risk of CNS depression Details Secobarbital Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Secobarbital Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Secobarbital Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Secobarbital Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Secobarbital Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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