Segesterone

18 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mitapivat Meropenem Meropenem Injection Methylergonovine Nevirapine Nifedipine
16 Major 2 Moderate
All (18) Major (16) Moderate (2)

Major

Segesterone Isotretinoin Absorica Explained Decreased effectiveness of hormonal contraceptives Details Segesterone Bexarotene Targretin Decreased contraceptive effectiveness Details Segesterone Bexarotene Topical Targretin Decreased contraceptive effectiveness Details Segesterone Dexamethasone Injection Decadron Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Segesterone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Segesterone Enasidenib Idhifa Reduced hormonal contraceptive exposure and reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleed... Details Segesterone Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Segesterone Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Segesterone Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Segesterone Meropenem Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Segesterone Meropenem Injection Merrem® Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Segesterone Methylergonovine Methergine Increased methylergonovine exposure Details Segesterone Mitapivat Aqvesme Reduced hormonal contraceptive exposure Details Segesterone Nafcillin Injection Unipen® Injection Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Segesterone Nevirapine Viramune Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Segesterone Nifedipine Adalat® Increased NIFEdipine exposure Details

Moderate

Segesterone Clopidogrel Plavix Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Segesterone Dofetilide Tikosyn Increased dofetilide exposure Details

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