Seladelpar and Lefamulin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Lefamulin
Seladelpar
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased seladelpar exposure
Interaction Deep Dive
Coadministration of seladelpar and moderate to strong CYP3A4 inhibitors may increase seladelpar exposure. If coadministered, monitor patients closely for adverse reactions1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of seladelpar
Literature reports
1 report — tap to read
a) In a drug interaction study in healthy subjects, seladelpar AUC (0-inf) increased by 2.4-fold and Cmax by 1.4-fold following concomitant use of a single 10 mg seladelpar dose with 400 mg fluconazole (CYP3A4 inhibitor) 1.
Common questions
Can I take Seladelpar and Lefamulin together?
Increased seladelpar exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Seladelpar and Lefamulin interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Seladelpar or Lefamulin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: LIVDELZI® oral capsules, seladelpar oral capsules. Gilead Sciences, Inc. (Per Manufacturer), Foster City, CA, 2026. DailyMed
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