Selexipag

41 interactions 3 explained in plain English
Also sold as: Uptravi Uptravi®
About Selexipag

Selexipag is used in adults to treat pulmonary arterial hypertension (PAH, high blood pressure in the vessels that carry blood to the lungs) to slow down the worsening of symptoms and reduce the chance of being hospitalized for PAH. Selexipag is in a class of medications called selective nonprostanoid IP prostacyclin r… Read the full Selexipag drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abrocitinib Gemfibrozil Edoxaban Naproxen Bromfenac Ophthalmic Ibuprofen
2 Contraindicated 35 Major 4 Moderate
All (41) Contraindicated (2) Major (35) Moderate (4)

Moderate

Selexipag Mitapivat Aqvesme Reduced CYP2C8 substrate exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.