Selexipag

41 interactions 3 explained in plain English
Also sold as: Uptravi Uptravi®
About Selexipag

Selexipag is used in adults to treat pulmonary arterial hypertension (PAH, high blood pressure in the vessels that carry blood to the lungs) to slow down the worsening of symptoms and reduce the chance of being hospitalized for PAH. Selexipag is in a class of medications called selective nonprostanoid IP prostacyclin r… Read the full Selexipag drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abrocitinib Gemfibrozil Edoxaban Naproxen Bromfenac Ophthalmic Ibuprofen
2 Contraindicated 35 Major 4 Moderate
All (41) Contraindicated (2) Major (35) Moderate (4)

Major

Selexipag Sertraline Explained An increased risk of bleeding Details Selexipag Apixaban Eliquis Explained Increased risk of bleeding and can cause serious, potentially fatal bleeding Details Selexipag Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Selexipag Clopidogrel Plavix Increased exposure of selexipag and its active metabolite and an increased risk of bleeding Details Selexipag Dabigatran Pradaxa® Increased risk of bleeding Details Selexipag Dabigatran Etexilate Increased risk of bleeding Details Selexipag Darolutamide Nubeqa Increased exposure of OATP1B1 or OATP1B3 substrates Details Selexipag Deferasirox Exjade Increased exposure of selexipag and its active metabolite Details Selexipag Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Selexipag Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Selexipag Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Selexipag Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Selexipag Edoxaban Savaysa Increased risk of bleeding Details Selexipag Etodolac Lodine An increased risk of bleeding Details Selexipag Fenoprofen Fenopron An increased risk of bleeding Details Selexipag Flurbiprofen Ansaid An increased risk of bleeding Details Selexipag Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Selexipag Fondaparinux Arixtra Increased risk of bleeding Details Selexipag Fondaparinux Injection Arixtra Increased risk of bleeding Details Selexipag Heparin Increased risk of bleeding Details Selexipag Heparin Injection Lipo-Hepin® Increased risk of bleeding Details Selexipag Ibuprofen Addaprin An increased risk of bleeding Details Selexipag Ketoprofen Actron® An increased risk of bleeding Details Selexipag Ketorolac Acular An increased risk of bleeding Details Selexipag Ketorolac Injection Acular An increased risk of bleeding Details Selexipag Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Selexipag Ketorolac Ophthalmic Acular An increased risk of bleeding Details Selexipag Leniolisib Joenja Increased OATP1B1/OATP1B3 substrate exposure Details Selexipag Letermovir Injection Prevymis Increased exposure of selexipag and its active metabolite Details Selexipag Meclofenamate Meclodium® An increased risk of bleeding Details Selexipag Mefenamic Acid Ponstel® An increased risk of bleeding Details Selexipag Meloxicam Alloxate An increased risk of bleeding Details Selexipag Meloxicam Injection Alloxate An increased risk of bleeding Details Selexipag Nabumetone Relafen An increased risk of bleeding Details Selexipag Naproxen Aleve An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.