Sibutramine
51 interactions 5 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Linezolid Injection
Metoclopramide Injection
Diethylpropion
Metoclopramide Nasal Spray
Palonosetron Injection
Edoxaban
Contraindicated
Sibutramine Diethylpropion Tenuate An increased risk of hypertension and tachycardia Details Sibutramine Linezolid Injection Zyvox CNS toxicity or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Sibutramine Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Sibutramine Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome DetailsMajor
Sibutramine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Sibutramine Amitriptyline Elavil Explained Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Sibutramine Sertraline Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Sibutramine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Sibutramine Apixaban Eliquis Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Sibutramine Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Sibutramine Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Sibutramine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Sibutramine Clopidogrel Plavix Increased risk of bleeding Details Sibutramine Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Sibutramine Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Sibutramine Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Sibutramine Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Sibutramine Dihydroergotamine Injection DHE-45® Injection An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Sibutramine Dihydroergotamine Nasal Spray Migranal An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Sibutramine Dolasetron Anzemet Increased risk of serotonin syndrome Details Sibutramine Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Sibutramine Edoxaban Savaysa Increased risk of bleeding Details Sibutramine Etodolac Lodine An increased risk of bleeding Details Sibutramine Fenoprofen Fenopron An increased risk of bleeding Details Sibutramine Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Sibutramine Flurbiprofen Ansaid An increased risk of bleeding Details Sibutramine Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Sibutramine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Sibutramine Granisetron Injection Granisol Increased risk of serotonin syndrome Details Sibutramine Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Sibutramine Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Sibutramine Hydroxychloroquine Plaquenil An increased risk of seizures Details Sibutramine Ibuprofen Addaprin An increased risk of bleeding Details Sibutramine Ketoconazole Topical Extina® Foam Increased sibutramine exposure Details Sibutramine Ketoprofen Actron® An increased risk of bleeding Details Sibutramine Ketorolac Acular An increased risk of bleeding Details Sibutramine Ketorolac Injection Acular An increased risk of bleeding Details Sibutramine Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Sibutramine Ketorolac Ophthalmic Acular An increased risk of bleeding Details Sibutramine Letermovir Injection Prevymis Increased CYP3A substrate exposure DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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