Sirolimus

Name: Sirolimus Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

43 interactions 4 explained in plain English

Also sold as: Felycin Fyarro Hyftor Rapamune Rapamune®

About Sirolimus

Sirolimus is an immunosuppressant medication used to prevent the body from rejecting a kidney transplant. Read the full Sirolimus drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lisinopril Methotrexate Asciminib Perindopril Belumosudil Cyclosporine Injection

36 Major 7 Moderate

All (43) Major (36) Moderate (7)

Moderate

Sirolimus Trospium / Xanomeline Cobenfy Explained Increased oral sensitive CYP3A4 substrate that are P-gp substrates with NTI exposure and an increased risk on severity and frequen... Details Sirolimus Clotrimazole Aardora Anti-Fungal Maximum Strength An increased risk of sirolimus toxicity (anemia, leukopenia, thrombocytopenia, hypokalemia, fever, diarrhea) Details Sirolimus Clotrimazole Lozenge Mycelex® An increased risk of sirolimus toxicity (anemia, leukopenia, thrombocytopenia, hypokalemia, fever, diarrhea) Details Sirolimus Clotrimazole Topical Cruex Antifungal An increased risk of sirolimus toxicity (anemia, leukopenia, thrombocytopenia, hypokalemia, fever, diarrhea) Details Sirolimus Clotrimazole Vaginal Gyne-Lotrimin 3® Cream An increased risk of sirolimus toxicity (anemia, leukopenia, thrombocytopenia, hypokalemia, fever, diarrhea) Details Sirolimus Danazol Danocrine® An increased risk of sirolimus toxicity (anemia, leukopenia, thrombocytopenia, hypokalemia, fever, diarrhea) Details Sirolimus Nicardipine Cardene An increased risk of sirolimus toxicity (anemia, leukopenia, thrombocytopenia, hypokalemia, diarrhea) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.