Sodium Oxybate

25 interactions 2 explained in plain English

Also sold as: Lumryz Xyrem Xywav

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Diphenhydramine Injection Diphenhydramine Topical Cetirizine Ophthalmic Nalbuphine Injection Butorphanol Injection Butorphanol Nasal Spray

2 Contraindicated 22 Major 1 Moderate

All (25) Contraindicated (2) Major (22) Moderate (1)

Major

Sodium Oxybate Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Buprenorphine Belbuca Explained An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Aripiprazole Injection Abilify An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Asenapine Transdermal Patch Secuado An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Butorphanol Injection Butorphic An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Butorphanol Nasal Spray Stadol® NS An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Cetirizine Injection Aller-Tec An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Cetirizine Ophthalmic Zerviate An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Diazepam Nasal Spray Valtoco An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Diazepam Rectal Diastat An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Esketamine Nasal Spray Spravato An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Fentanyl Transdermal Patch Duragesic® An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Hydromorphone Injection Dilaudid An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Hydromorphone Rectal available generically An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Lacosamide Injection Motpoly An increased risk of CNS depression Details Sodium Oxybate Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Sodium Oxybate Metoclopramide Injection Gimoti An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Metoclopramide Nasal Spray Gimoti An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Midazolam Nasal Spray Nayzilam An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Midazolam Injection Nayzilam An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Morphine Injection Astramorph® PF An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Sodium Oxybate Nalbuphine Injection Nubain® An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details

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