Sodium Salicylate

85 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Ophthalmic Ketorolac Nasal Spray Pemetrexed Injection Aspirin
4 Contraindicated 53 Major 28 Moderate
All (85) Contraindicated (4) Major (53) Moderate (28)

Major

Sodium Salicylate Meclofenamate Meclodium® Increased risk of bleeding Details Sodium Salicylate Mefenamic Acid Ponstel® Increased risk of bleeding Details Sodium Salicylate Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Sodium Salicylate Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Sodium Salicylate Melphalan Alkeran An increased risk of bleeding Details Sodium Salicylate Melphalan Injection Alkeran An increased risk of bleeding Details Sodium Salicylate Mesalamine Apriso Increased risk of bleeding Details Sodium Salicylate Mesalamine Rectal Canasa Increased risk of bleeding Details Sodium Salicylate Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Sodium Salicylate Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Sodium Salicylate Nabumetone Relafen Increased risk of bleeding Details Sodium Salicylate Naproxen Aleve Increased risk of bleeding Details Sodium Salicylate Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.