Sodium Salicylate

85 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Ophthalmic Ketorolac Nasal Spray Pemetrexed Injection Aspirin
4 Contraindicated 53 Major 28 Moderate
All (85) Contraindicated (4) Major (53) Moderate (28)

Moderate

Sodium Salicylate Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Sodium Salicylate Atenolol Tenormin Explained Reduced antihypertensive effect Details Sodium Salicylate Acebutolol Sectral® Reduced antihypertensive effect Details Sodium Salicylate Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Sodium Salicylate Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Sodium Salicylate Betaxolol Betoptic S Reduced antihypertensive effect Details Sodium Salicylate Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Sodium Salicylate Bisoprolol Zebeta® Reduced antihypertensive effect Details Sodium Salicylate Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Sodium Salicylate Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Sodium Salicylate Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Sodium Salicylate Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Sodium Salicylate Esmolol Brevibloc Reduced antihypertensive effect Details Sodium Salicylate Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Sodium Salicylate Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Sodium Salicylate Labetalol Normodyne® Reduced antihypertensive effect Details Sodium Salicylate Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Sodium Salicylate Levofloxacin Levaquin An increased risk of seizures Details Sodium Salicylate Levofloxacin Injection Levaquin An increased risk of seizures Details Sodium Salicylate Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Sodium Salicylate Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Sodium Salicylate Nadolol Corgard Reduced antihypertensive effect Details Sodium Salicylate Nebivolol Bystolic Reduced antihypertensive effect Details Sodium Salicylate Ofloxacin Floxin® An increased risk of seizures Details Sodium Salicylate Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Sodium Salicylate Ofloxacin Otic Floxin® Otic An increased risk of seizures Details Sodium Salicylate Penbutolol Levatol® Reduced antihypertensive effect Details Sodium Salicylate Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.