Solifenacin

72 interactions 6 explained in plain English

Also sold as: Vesicare

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Eribulin Injection Felbamate Sertraline Levofloxacin Injection Dasatinib

1 Contraindicated 70 Major 1 Moderate

All (72) Contraindicated (1) Major (70) Moderate (1)

Major

Solifenacin Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Solifenacin Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Solifenacin Granisetron Injection Granisol An increased risk of QT interval prolongation Details Solifenacin Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Solifenacin Hydromorphone Injection Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Solifenacin Hydromorphone Rectal available generically Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Solifenacin Hydroxychloroquine Plaquenil An increased risk of seizures and an increased risk of QT interval prolongation Details Solifenacin Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Solifenacin Ivabradine Corlanor Increased risk of QT prolongation Details Solifenacin Lefamulin Xenleta Increased risk of QT interval prolongation Details Solifenacin Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Solifenacin Levofloxacin Levaquin Increased risk of QT interval prolongation Details Solifenacin Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Solifenacin Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Solifenacin Mefloquine Lariam® An increased risk of QT interval prolongation Details Solifenacin Metronidazole Flagyl An increased risk of QT interval prolongation Details Solifenacin Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Solifenacin Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Solifenacin Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Solifenacin Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, and paralytic ileus Details Solifenacin Moxifloxacin Avelox Increased risk of QT interval prolongation Details Solifenacin Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Solifenacin Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Solifenacin Octreotide Bynfezia An increased risk of QT interval prolongation Details Solifenacin Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Solifenacin Ofloxacin Floxin® An increased risk of QT interval prolongation Details Solifenacin Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Solifenacin Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Solifenacin Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Solifenacin Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.