Solifenacin

72 interactions 6 explained in plain English
Also sold as: Vesicare
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Eribulin Injection Felbamate Sertraline Levofloxacin Injection Dasatinib
1 Contraindicated 70 Major 1 Moderate
All (72) Contraindicated (1) Major (70) Moderate (1)

Contraindicated

Solifenacin Ketoconazole Topical Extina® Foam Increased solifenacin exposure and increased risk of QT interval prolongation Details

Major

Solifenacin Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of paralytic ileus Details Solifenacin Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Solifenacin Sertraline Explained An increased risk of QT interval prolongation Details Solifenacin Buprenorphine Belbuca Explained An increased risk of paralytic ileus and an increased risk of QT interval prolongation Details Solifenacin Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Solifenacin Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Solifenacin Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Solifenacin Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Solifenacin Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Solifenacin Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Solifenacin Azithromycin AzaSite An increased risk of QT interval prolongation Details Solifenacin Alfuzosin UroXatral An increased risk of QT interval prolongation Details Solifenacin Anagrelide Agrylin Increased risk of QT interval prolongation Details Solifenacin Bedaquiline Sirturo An increased risk of QT interval prolongation Details Solifenacin Chloroquine Aralen® An increased risk of QT interval prolongation Details Solifenacin Dasatinib Phyrago An increased risk of QT interval prolongation Details Solifenacin Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Solifenacin Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Solifenacin Disopyramide Norpace An increased risk of QT interval prolongation Details Solifenacin Dofetilide Tikosyn An increased risk of QT interval prolongation Details Solifenacin Dolasetron Anzemet An increased risk of QT interval prolongation Details Solifenacin Dolasetron Injection Anzemet An increased risk of QT interval prolongation Details Solifenacin Encorafenib Braftovi Increased risk of QT interval prolongation Details Solifenacin Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Solifenacin Eribulin Injection Halaven An increased risk of QT interval prolongation Details Solifenacin Famotidine Calmicid An increased risk of QT interval prolongation Details Solifenacin Famotidine Injection Calmicid An increased risk of QT interval prolongation Details Solifenacin Felbamate Felbatol An increased risk of QT interval prolongation Details Solifenacin Fentanyl Transdermal Patch Duragesic® Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Solifenacin Flecainide Tambocor® An increased risk of QT interval prolongation Details Solifenacin Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Solifenacin Fostemsavir Rukobia Increased risk of torsade de pointes Details Solifenacin Galantamine Razadyne An increased risk of QT interval prolongation Details Solifenacin Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Solifenacin Gemifloxacin Factive An increased risk of QT interval prolongation Details Solifenacin Glasdegib Daurismo Increased risk of QT interval prolongation Details Solifenacin Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Solifenacin Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Solifenacin Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.