Sparfloxacin

92 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Felbamate Sertraline Oxaliplatin Injection Eribulin Injection Dasatinib Levofloxacin Injection
63 Contraindicated 28 Major 1 Moderate
All (92) Contraindicated (63) Major (28) Moderate (1)

Contraindicated

Sparfloxacin Ivabradine Corlanor An increased risk of QT interval prolongation Details Sparfloxacin Ketoconazole Topical Extina® Foam An increased risk of QT interval prolongation Details Sparfloxacin Lefamulin Xenleta An increased risk of QT interval prolongation Details Sparfloxacin Lenvatinib Lenvima An increased risk of QT interval prolongation Details Sparfloxacin Levofloxacin Levaquin An increased risk of QT interval prolongation Details Sparfloxacin Levofloxacin Injection Levaquin An increased risk of QT interval prolongation Details Sparfloxacin Loperamide Diamode An increased risk of QT interval prolongation Details Sparfloxacin Mefloquine Lariam® An increased risk of QT interval prolongation Details Sparfloxacin Metronidazole Flagyl An increased risk of QT interval prolongation Details Sparfloxacin Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Sparfloxacin Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Sparfloxacin Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Sparfloxacin Moxifloxacin Avelox An increased risk of QT interval prolongation Details Sparfloxacin Moxifloxacin Injection Avelox An increased risk of QT interval prolongation Details Sparfloxacin Moxifloxacin Ophthalmic Moxeza® An increased risk of QT interval prolongation Details Sparfloxacin Nafarelin Nasal Spray Synarel An increased risk of QT interval prolongation Details Sparfloxacin Octreotide Bynfezia An increased risk of QT interval prolongation Details Sparfloxacin Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Sparfloxacin Ofloxacin Floxin® An increased risk of QT interval prolongation Details Sparfloxacin Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Sparfloxacin Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Sparfloxacin Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation Details Sparfloxacin Oxaliplatin Injection Eloxatin® An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.