Stavudine

Name: Stavudine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

5 interactions

Also sold as: Zerit®

About Stavudine

Stavudine is used along with other medications to treat human immunodeficiency virus (HIV) infection. Stavudine is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood. Although stavudine does not cure HIV, it may decrease your chanc… Read the full Stavudine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Didanosine Cabotegravir Doxorubicin Hydroxyurea Orlistat

1 Contraindicated 4 Major

All (5) Contraindicated (1) Major (4)

Contraindicated

Stavudine Didanosine Videx® Increased risk of lactic acidosis, hepatotoxicity, peripheral neuropathy, and pancreatitis Details

Major

Stavudine Cabotegravir Apretude Loss of virologic response and possible development of viral resistance Details Stavudine Doxorubicin Adriamycin Decreased stavudine efficacy Details Stavudine Hydroxyurea Droxia Increased risk of severe peripheral neuropathy, increased risk of fatal pancreatitis and hepatotoxicity Details Stavudine Orlistat Alli Reduced efficacy of antiretrovirals, loss of virological control Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.