Streptomycin and Carboplatin Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Carboplatin Injection
Streptomycin
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Ototoxicity
Interaction Deep Dive
Concomitant administration of CARBOplatin and aminoglycoside antibiotics may increase the risk of ototoxicity. In a case report, five of 16 patients receiving CARBOplatin (200 to 300 mg/m(2) daily) for five days experienced hearing loss. All five patients, however, had prior exposure to aminoglycosides1.
Why it happens (mechanism)
Additive ototoxic effects
Common questions
Can I take Streptomycin and Carboplatin Injection together?
Ototoxicity Always confirm with your pharmacist or prescriber before making any change.
How serious is the Streptomycin and Carboplatin Injection interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Streptomycin or Carboplatin Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Lee EJ, Egorin MJ, Van Echo DA, et al: Phase I and pharmacokinetic trial of carboplatin in refractory adult leukemia. J Natl Cancer Inst 1988; 80:131-135. PubMed
Keep reading about Carboplatin Injection
Keep reading about Streptomycin
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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