Streptomycin

19 interactions
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Aspirin Aspirin Rectal Ascorbic Acid (Vitamin C) Foscarnet Injection Cidofovir Injection Colistimethate Injection
9 Major 4 Moderate 6 Minor
All (19) Major (9) Moderate (4) Minor (6)

Major

Streptomycin Aspirin Acuprin® Increased aspirin exposure and an increased risk of nephrotoxicity Details Streptomycin Aspirin Rectal Aspirin Increased aspirin exposure and an increased risk of nephrotoxicity Details Streptomycin Ascorbic Acid (Vitamin C) C-500® Chewable Tablet Decreased streptomycin efficacy Details Streptomycin Cefepime Injection Maxipime® An increased risk of nephrotoxicity and an increased risk of ototoxicity Details Streptomycin Cidofovir Injection Vistide® Nephrotoxicity Details Streptomycin Colistimethate Injection Coly-Mycin M® Respiratory depression Details Streptomycin Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Streptomycin Foscarnet Injection Foscavir Nephrotoxicity Details Streptomycin Furosemide Injection Disal An increased risk of ototoxicity Details

Moderate

Streptomycin Carboplatin Kyxata Ototoxicity Details Streptomycin Carboplatin Injection Kyxata Ototoxicity Details Streptomycin Cyclosporine Injection Atopica Renal dysfunction or nephrotoxicity Details Streptomycin Cyclosporine Ophthalmic Cequa Renal dysfunction or nephrotoxicity Details

Minor

Streptomycin Amoxicillin Amoxi Drop Loss of aminoglycoside efficacy Details Streptomycin Ampicillin Amcill® Loss of aminoglycoside efficacy Details Streptomycin Ampicillin Injection Omnipen-N® Loss of aminoglycoside efficacy Details Streptomycin Nafcillin Injection Unipen® Injection Loss of aminoglycoside efficacy Details Streptomycin Penicillin G Procaine Injection Bactracillin G Loss of aminoglycoside efficacy Details Streptomycin Penicillin V Potassium Beepen-VK® Loss of aminoglycoside efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.