Sulfamethizole

Name: Sulfamethizole Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

12 interactions

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Gemifloxacin Meloxicam Meloxicam Injection Methotrexate Methotrexate Injection

5 Major 7 Moderate

All (12) Major (5) Moderate (7)

Major

Sulfamethizole Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sulfamethizole Meloxicam Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Sulfamethizole Meloxicam Injection Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Sulfamethizole Methotrexate Jylamvo An increased risk of methotrexate toxicity (myelotoxicity, pancytopenia, megaloblastic anemia) Details Sulfamethizole Methotrexate Injection Abitrexate® An increased risk of methotrexate toxicity (myelotoxicity, pancytopenia, megaloblastic anemia) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.