Drug Interaction Report

Sultopride and Octreotide: Interaction Details

A pharmacist-reviewed analysis of the Sultopride and Octreotide interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Octreotide

Bynfezia Mycapssa Mycapssa® Sandostatin
+

Sultopride

No brand names on record
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 44 documented Sultopride interactions, 44 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest)

Interaction Deep Dive

Octreotide has been shown to prolong the QTc interval at the recommended therapeutic dose7. Even though no formal drug interaction studies have been done, the coadministration of antipsychotics and other drugs known to prolong the QTc interval, including octreotide, is not recommended. Several antipsychotic agents have demonstrated QT prolongation including haloperidol 3, risperidone 4, sertindole 5, quetiapine 1, sultopride 2, and zotepine 6.

Why it happens (mechanism)

Additive effects on QT prolongation

Common questions

Can I take Sultopride and Octreotide together?

An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Always confirm with your pharmacist or prescriber before making any change.

How serious is the Sultopride and Octreotide interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Sultopride or Octreotide need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (7)

  1. Owens R: Risk assessment for antimicrobial agent-induced QTc prolongation and torsades de pointes. Pharmacother 2001; 21(3):310-319.
  2. Lande G, Drouin E, Gauthier C, et al: Arrhythmogenic effects of sultopride chlorhydrate: clinical and cellular electrophysiological correlation. Ann Fr Anesth Reanim 1992; 11:629-635.
  3. O'Brien JM, Rockwood RP, & Suh KI: Haloperidol-induced torsade de pointes. Ann Pharmacother 1999; 33(10):1046-1050. DOI
  4. Duenas-Laita A, Castro-Villamor MA, Martin-Escudero JC, et al: New clinical manifestations of acute risperidone poisoning (letter). Clin Toxicol 1999; 37(7):893-894. PubMed
  5. Agelink MW, Zeit T, Baumann B, et al: In vivo cardiovascular effects of the new atypical neuroleptic sertindole. Int J Psychiatry Clin Pract 2001; 5:33-40. DOI
  6. Sweetman S (Ed): Martindale: The Complete Drug Reference. London: Pharmaceutical Press. Electronic version, MICROMEDEX, Greenwood Village, Colorado, Edition expires 06/2003.
  7. Product Information: Sandostatin(R), octreotide. Novartis Pharmaceuticals, East Hanover, NJ, 1999. DailyMed
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Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Octreotide + Activated Charcoal Adrafinil Cannabidiol (cbd) Cannabinol (cbn) Cannabis Coffee Charcoal Delta-9-tetrahydrocannabinol (thc) Ergot + 22 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.