Sumatriptan

22 interactions 4 explained in plain English
Also sold as: Imitrex Onzetra Tosymra Zembrace
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dihydroergotamine Nasal Spray Linezolid Injection Methylergonovine Dihydroergotamine Injection Sertraline Butorphanol Injection
4 Contraindicated 18 Major
All (22) Contraindicated (4) Major (18)

Major

Sumatriptan Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Sumatriptan Amitriptyline Elavil Explained Increased risk of serotonin syndrome Details Sumatriptan Sertraline Explained An increased risk of serotonin syndrome Details Sumatriptan Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Sumatriptan Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Sumatriptan Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Sumatriptan Dolasetron Anzemet Increased risk of serotonin syndrome Details Sumatriptan Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Sumatriptan Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Sumatriptan Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Sumatriptan Granisetron Injection Granisol Increased risk of serotonin syndrome Details Sumatriptan Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Sumatriptan Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Sumatriptan Hydroxychloroquine Plaquenil An increased risk of seizures Details Sumatriptan Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Sumatriptan Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Sumatriptan Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details Sumatriptan Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.