Tafenoquine

Name: Tafenoquine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

3 interactions

Also sold as: Arakoda Arakoda® Kodatef Krintafel Krintafel®

About Tafenoquine

Tafenoquine (Krintafel) is used to prevent the return of malaria (a serious infection that is spread by mosquitoes in certain parts of the world and can cause death) in people 16 years of age and older who are infected and are currently receiving chloroquine or hydroxychloroquine to treat malaria. Tafenoquine (Arakoda)… Read the full Tafenoquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dofetilide Metformin

2 Major 1 Moderate

All (3) Major (2) Moderate (1)

Major

Tafenoquine Dofetilide Tikosyn Increased plasma concentrations of OCT2 and MATE substrates Details Tafenoquine Metformin Fortamet® Increased plasma concentrations of OCT2 and MATE substrates Details

Moderate

Tafenoquine Lanthanum Fosrenol® Reduced bioavailability of antimalarials Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.