Tamsulosin

21 interactions 2 explained in plain English
Also sold as: Flomax Flomax®
About Tamsulosin

Tamsulosin is an alpha blocker used to treat urinary symptoms caused by an enlarged prostate in men. Read the full Tamsulosin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sertraline Melphalan Injection Alfuzosin Doxazosin Ketoconazole Topical Letermovir Injection
8 Major 13 Moderate
All (21) Major (8) Moderate (13)

Major

Tamsulosin Sertraline Explained Increased CYP2D6 substrate exposure Details Tamsulosin Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Tamsulosin Alfuzosin UroXatral Increased effects of alpha adrenergic blockade Details Tamsulosin Doxazosin Cardura Increased effects of alpha adrenergic blockade Details Tamsulosin Ketoconazole Topical Extina® Foam Increased tamsulosin exposure and may also increase tamsulosin-related adverse reactions Details Tamsulosin Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Tamsulosin Melphalan Alkeran An increased risk of severe hypotension Details Tamsulosin Melphalan Injection Alkeran An increased risk of severe hypotension Details

Moderate

Tamsulosin Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Tamsulosin Atenolol Tenormin Explained An exaggerated hypotensive response to the first dose of the alpha blocker Details Tamsulosin Acebutolol Sectral® An exaggerated hypotensive response to the first dose of the alpha blocker Details Tamsulosin Avanafil Stendra Increased risk of hypotension Details Tamsulosin Betaxolol Betoptic S An exaggerated hypotensive response to the first dose of the alpha blocker Details Tamsulosin Betaxolol Ophthalmic Betoptic® An exaggerated hypotensive response to the first dose of the alpha blocker Details Tamsulosin Bisoprolol Zebeta® An exaggerated hypotensive response to the first dose of the alpha blocker Details Tamsulosin Esmolol Brevibloc An exaggerated hypotensive response to the first dose of the alpha blocker Details Tamsulosin Labetalol Normodyne® An exaggerated hypotensive response to the first dose of the alpha blocker Details Tamsulosin Levobunolol Ophthalmic AKBeta® An exaggerated hypotensive response to the first dose of the alpha blocker Details Tamsulosin Nadolol Corgard An exaggerated hypotensive response to the first dose of the alpha blocker Details Tamsulosin Nebivolol Bystolic An exaggerated hypotensive response to the first dose of the alpha blocker Details Tamsulosin Penbutolol Levatol® An exaggerated hypotensive response to the first dose of the alpha blocker Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.