Tapentadol

45 interactions 5 explained in plain English
Also sold as: Nucynta
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Tapentadol Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Tapentadol Amitriptyline Elavil Explained An increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Tapentadol Sertraline Explained An increased risk of serotonin syndrome Details Tapentadol Buprenorphine Belbuca Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome, respiratory depress... Details Tapentadol Trospium / Xanomeline Cobenfy Explained An increased risk of paralytic ileus Details Tapentadol Aripiprazole Injection Abilify An increased risk of respiratory and CNS depression Details Tapentadol Asenapine Transdermal Patch Secuado An increased risk of respiratory and CNS depression Details Tapentadol Aclidinium Oral Inhalation Tudorza An increased risk of paralytic ileus Details Tapentadol Atropine Ophthalmic Atropine Care 1% An increased risk of paralytic ileus Details Tapentadol Butorphanol Injection Butorphic Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome, respiratory depress... Details Tapentadol Butorphanol Nasal Spray Stadol® NS Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome, respiratory depress... Details Tapentadol Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Tapentadol Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Tapentadol Clopidogrel Plavix Reduced efficacy of clopidogrel Details Tapentadol Cyclopentolate Ophthalmic Akpentolate® An increased risk of paralytic ileus Details Tapentadol Diazepam Nasal Spray Valtoco An increased risk of CNS depression and an increased risk of respiratory depression, profound sedation, coma and death. Details Tapentadol Diazepam Rectal Diastat An increased risk of CNS depression and an increased risk of respiratory depression, profound sedation, coma and death. Details Tapentadol Diphenhydramine Injection Banophen An increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Tapentadol Diphenhydramine Topical Afterbite with Antihistamine An increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Tapentadol Dolasetron Anzemet Increased risk of serotonin syndrome Details Tapentadol Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Tapentadol Esketamine Nasal Spray Spravato Increased risk of sedation Details Tapentadol Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Tapentadol Furosemide Injection Disal Reduced efficacy of diuretics Details Tapentadol Glycopyrronium Topical Cuvposa® An increased risk of paralytic ileus Details Tapentadol Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Tapentadol Granisetron Injection Granisol Increased risk of serotonin syndrome Details Tapentadol Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Tapentadol Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Tapentadol Hydroxychloroquine Plaquenil An increased risk of seizures Details Tapentadol Ipratropium Nasal Spray Atrovent Nasal Spray® An increased risk of paralytic ileus Details Tapentadol Ipratropium Oral Inhalation Atrovent® HFA An increased risk of paralytic ileus Details Tapentadol Lacosamide Injection Motpoly An increased risk of CNS depression Details Tapentadol Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Tapentadol Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Tapentadol Metoclopramide Injection Gimoti Increased risk of CNS depression Details Tapentadol Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Tapentadol Midazolam Nasal Spray Nayzilam An increased risk of CNS depression and an increased risk of respiratory depression, profound sedation, coma and death. Details Tapentadol Midazolam Injection Nayzilam An increased risk of CNS depression and an increased risk of respiratory depression, profound sedation, coma and death. Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.