Teduglutide and Diazepam Nasal Spray: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Diazepam Nasal Spray
Teduglutide
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased exposure of orally administered benzodiazepines
Interaction Deep Dive
Coadministration of teduglutide with an oral medication that requires titration, such as a benzodiazepine, may significantly increase absorption of the benzodiazepine. In clinical trials, a patient taking a benzodiazepine who was treated with concomitant teduglutide experienced altered mental status that progressed to coma. A reduced dose of oral drugs requiring titration (eg, benzodiazepines) may be necessary when administered concomitantly with teduglutide1. If coadministration is necessary, the patient should be monitored for increased benzodiazepine side effects.
Why it happens (mechanism)
Unknown
Literature reports
1 report — tap to read
a) In a placebo-controlled clinical trial of teduglutide in adults with short bowel syndrome who were dependent on parenteral nutrition support, 1 woman who received teduglutide 0.05 mg/kg/day with concomitant oral prazepam had a dramatic deterioration in mental status, progressing to coma during the first week of study treatment. The level of prazepam in her blood was more than 300 mcg/L upon being admitted to the ICU. The coma resolved 5 days after teduglutide and prazepam were discontinued 1.
Common questions
Can I take Teduglutide and Diazepam Nasal Spray together?
Increased exposure of orally administered benzodiazepines Always confirm with your pharmacist or prescriber before making any change.
How serious is the Teduglutide and Diazepam Nasal Spray interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Teduglutide or Diazepam Nasal Spray need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: GATTEX(R) subcutaneous injection powder, teduglutide (rDNA origin) subcutaneous injection powder. Hospira, Inc. (per manufacturer), McPherson, KS, 2012. DailyMed
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