Diazepam Nasal Spray

281 interactions 1,109 cited references

Also sold as: Valtoco Valtoco®

About Diazepam Nasal Spray

Diazepam nasal spray is used for emergency situations to stop cluster seizures (episodes of increased seizure activity) in adults and children 6 years of age and older who are taking other medications to treat epilepsy (seizures). Diazepam is in a class of medications called benzodiazepines. It works by calming abnorma… Read the full Diazepam Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isocarboxazid Flumazenil Ensitrelvir Zuranolone Omaveloxolone Oliceridine

3 Contraindicated 220 Major 52 Moderate 6 Minor

All (281) Contraindicated (3) Major (220) Moderate (52) Minor (6)

Contraindicated

Diazepam Nasal Spray Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Diazepam Nasal Spray Flumazenil Increased risk of serious adverse effects in patients who are physically dependent on benzodiazepines, including seizures Details Diazepam Nasal Spray Isocarboxazid Marplan An increased risk of CNS depression Details

Major

Diazepam Nasal Spray Abametapir Increased exposure of CYP3A4 substrate Details Diazepam Nasal Spray Acepromazine PROMACE Increased risk of CNS depression Details Diazepam Nasal Spray Alfentanil Increased risk of respiratory or CNS depression and hypotension Details Diazepam Nasal Spray Alprazolam Xanax Increased risk of CNS depression Details Diazepam Nasal Spray Amobarbital Amytal An increased risk of CNS and respiratory depression Details Diazepam Nasal Spray Anileridine Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Diazepam Nasal Spray Apalutamide Erleada Reduced CYP2C19/CYP3A4 substrate exposure Details Diazepam Nasal Spray Aprepitant Aponvie Increased exposure to benzodiazepines and an increased risk of benzodiazepine-related adverse reactions Details Diazepam Nasal Spray Aripiprazole Abilify Increased risk of CNS depression and orthostatic hypotension Details Diazepam Nasal Spray Aripiprazole Lauroxil Aristada Increased risk of CNS depression and orthostatic hypotension Details Diazepam Nasal Spray Asenapine Saphris Increased risk of CNS depression Details Diazepam Nasal Spray Avacopan Tavneos Increased CYP3A4 substrate exposure Details Diazepam Nasal Spray Baclofen Fleqsuvy Increased risk of CNS depression Details Diazepam Nasal Spray Benperidol Increased risk of CNS depression Details Diazepam Nasal Spray Benzhydrocodone Increased risk of respiratory and CNS depression Details Diazepam Nasal Spray Bromazepam Increased risk of respiratory or cardiovascular depression Details Diazepam Nasal Spray Bromopride Potentiation of sedative effects Details Diazepam Nasal Spray Buprenorphine Belbuca An increased risk of CNS depression and respiratory depression Details Diazepam Nasal Spray Buspirone Bucapsol Increased risk of CNS depression Details Diazepam Nasal Spray Butabarbital An increased risk of CNS and respiratory depression Details Diazepam Nasal Spray Butalbital An increased risk of CNS depression Details Diazepam Nasal Spray Butorphanol Butorphic Increased risk of respiratory and CNS depression Details Diazepam Nasal Spray Calcifediol Rayaldee Altered serum levels of calcifediol Details Diazepam Nasal Spray Calcium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Diazepam Nasal Spray Cannabidiol Epidiolex Increased CYP2C19 substrate exposure, an increased risk of CYP2C19 substrate-related adverse reactions, an increased risk of CNS d... Details Diazepam Nasal Spray Cannabis An increased risk of CNS depression Details Diazepam Nasal Spray Carbamazepine Carbatrol Reduced diazePAM exposure, reduced diazePAM efficacy and an increased risk of respiratory depression, profound sedation, hypotensi... Details Diazepam Nasal Spray Carbidopa Lodosyn An increased risk of CNS depression Details Diazepam Nasal Spray Carbinoxamine Carbzah An increased risk of CNS depression Details Diazepam Nasal Spray Carisoprodol Soma Additive respiratory depression Details Diazepam Nasal Spray Carphenazine Increased risk of CNS depression Details Diazepam Nasal Spray Cetirizine Aller-Tec Increased risk of CNS depression Details Diazepam Nasal Spray Chloral Hydrate Additive respiratory depression Details Diazepam Nasal Spray Chlordiazepoxide Increased risk of CNS depression Details Diazepam Nasal Spray Chlorpromazine Increased risk of CNS depression Details Diazepam Nasal Spray Chlorzoxazone Lorzone Additive respiratory depression Details Diazepam Nasal Spray Clarithromycin Biaxin Increased exposure of CYP3A4 substrate and risk for toxicity Details

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