Tenapanor

Name: Tenapanor Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

1 interactions

Also sold as: Ibsrela®

About Tenapanor

Tenapanor is used to treat irritable bowel syndrome with constipation (IBS-C; a condition that causes stomach pain or cramps, bloating, and infrequent or difficult passage of stools) in adults. Tenapanor is in a class of medications called sodium/hydrogen exchanger (NHE3) inhibitors. It works by increasing the movement… Read the full Tenapanor drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Enalapril

1 Major

All (1) Major (1)

Major

Tenapanor Enalapril Epaned Reduced enalapril and enalapril active metabolite (enalaprilat) exposure, reduced efficacy of enalapril Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.