Tenofovir Alafenamide

67 interactions 1 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acyclovir Acyclovir Injection Capmatinib Bromfenac Ophthalmic Aspirin Gentamicin Injection

45 Major 22 Moderate

All (67) Major (45) Moderate (22)

Major

Tenofovir Alafenamide Meloxicam Alloxate Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Tenofovir Alafenamide Meloxicam Injection Alloxate Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Tenofovir Alafenamide Midostaurin Rydapt Increased tenofovir alafenamide exposure Details Tenofovir Alafenamide Nabumetone Relafen Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Tenofovir Alafenamide Naproxen Aleve Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details

Moderate

Tenofovir Alafenamide Abrocitinib Cibinqo Explained Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Tenofovir Alafenamide Azithromycin AzaSite Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Tenofovir Alafenamide Atorvastatin Atorvaliq Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Tenofovir Alafenamide Alogliptin Nesina Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Tenofovir Alafenamide Brigatinib Alunbrig Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Tenofovir Alafenamide Canagliflozin Invokana Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Tenofovir Alafenamide Captopril Capoten® Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Tenofovir Alafenamide Cyclosporine Injection Atopica Increased tenofovir alafenamide or tenofovir disoproxil fumarate exposure Details Tenofovir Alafenamide Cyclosporine Ophthalmic Cequa Increased tenofovir alafenamide or tenofovir disoproxil fumarate exposure Details Tenofovir Alafenamide Elacestrant Orserdu Increased tenofovir alafenamide or tenofovir disoproxil fumarate exposure Details Tenofovir Alafenamide Encorafenib Braftovi Increased BCRP substrate exposure and an increased risk of BCRP substrate-related toxicities Details Tenofovir Alafenamide Entrectinib Rozlytrek Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Tenofovir Alafenamide Felodipine Plendil® Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Tenofovir Alafenamide Fostamatinib Tavalisse Increased tenofovir alafenamide or tenofovir disoproxil fumarate exposure Details Tenofovir Alafenamide Ibrexafungerp Brexafemme Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Tenofovir Alafenamide Ibrutinib Imbruvica Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Tenofovir Alafenamide Istradefylline Nourianz Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Tenofovir Alafenamide Ketoconazole Topical Extina® Foam Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Tenofovir Alafenamide Lenacapavir Injection Sunlenca Increased tenofovir alafenamide or tenofovir disoproxil fumarate exposure Details Tenofovir Alafenamide Lenacapavir Oral Sunlenca Increased tenofovir alafenamide or tenofovir disoproxil fumarate exposure Details Tenofovir Alafenamide Neratinib Nerlynx Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Tenofovir Alafenamide Nifedipine Adalat® Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.