Tiaprofenic Acid

91 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Tiaprofenic Acid Fondaparinux Injection Arixtra An increased risk of bleeding Details Tiaprofenic Acid Furosemide Injection Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Tiaprofenic Acid Heparin An increased risk of bleeding Details Tiaprofenic Acid Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Tiaprofenic Acid Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Tiaprofenic Acid Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Tiaprofenic Acid Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Tiaprofenic Acid Iloprost Aurlumyn An increased risk of bleeding Details Tiaprofenic Acid Ketoprofen Actron® Increased risk of bleeding Details Tiaprofenic Acid Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Tiaprofenic Acid Meclofenamate Meclodium® Increased risk of bleeding Details Tiaprofenic Acid Mefenamic Acid Ponstel® Increased risk of bleeding Details Tiaprofenic Acid Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Tiaprofenic Acid Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Tiaprofenic Acid Melphalan Alkeran An increased risk of bleeding Details Tiaprofenic Acid Melphalan Injection Alkeran An increased risk of bleeding Details Tiaprofenic Acid Mesalamine Apriso Increased risk of bleeding Details Tiaprofenic Acid Mesalamine Rectal Canasa Increased risk of bleeding Details Tiaprofenic Acid Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tiaprofenic Acid Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tiaprofenic Acid Nabumetone Relafen Increased risk of bleeding Details Tiaprofenic Acid Naproxen Aleve Increased risk of bleeding Details Tiaprofenic Acid Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

Moderate

Tiaprofenic Acid Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tiaprofenic Acid Atenolol Tenormin Explained Reduced antihypertensive effect Details Tiaprofenic Acid Acebutolol Sectral® Reduced antihypertensive effect Details Tiaprofenic Acid Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tiaprofenic Acid Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tiaprofenic Acid Betaxolol Betoptic S Reduced antihypertensive effect Details Tiaprofenic Acid Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Tiaprofenic Acid Bisoprolol Zebeta® Reduced antihypertensive effect Details Tiaprofenic Acid Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tiaprofenic Acid Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Tiaprofenic Acid Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tiaprofenic Acid Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tiaprofenic Acid Esmolol Brevibloc Reduced antihypertensive effect Details Tiaprofenic Acid Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tiaprofenic Acid Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tiaprofenic Acid Labetalol Normodyne® Reduced antihypertensive effect Details Tiaprofenic Acid Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.