Timolol

60 interactions 3 explained in plain English

Also sold as: Betimol Blocadren® Istalol Timoptic

About Timolol

Timolol is a beta blocker used to treat high blood pressure, prevent migraines, and improve survival after a heart attack. Read the full Timolol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sertraline Albuterol Oral Inhalation Abiraterone Clonidine Transdermal Patch Indacaterol Oral Inhalation Lacosamide Injection

8 Major 52 Moderate

All (60) Major (8) Moderate (52)

Moderate

Timolol Acarbose Prandase® Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Timolol Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Timolol Aspirin Acuprin® Reduced antihypertensive effect Details Timolol Aspirin Rectal Aspirin Reduced antihypertensive effect Details Timolol Alfuzosin UroXatral An exaggerated hypotensive response to the first dose of the alpha blocker Details Timolol Alogliptin Nesina Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Timolol Bromfenac Ophthalmic Bromday® Reduced antihypertensive effect Details Timolol Canagliflozin Invokana Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Timolol Dapagliflozin Farxiga Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Timolol Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect Details Timolol Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect Details Timolol Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect Details Timolol Diclofenac Transdermal Patch Flector Reduced antihypertensive effect Details Timolol Digoxin Cardoxin® Increased risk of bradycardia and possible digitalis glycoside toxicity Details Timolol Doxazosin Cardura An exaggerated hypotensive response to the first dose of the alpha blocker Details Timolol Dulaglutide Injection Trulicity Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Timolol Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Timolol Ertugliflozin Steglatro Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Timolol Etodolac Lodine Reduced antihypertensive effect Details Timolol Exenatide Injection Bydureon Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Timolol Fenoprofen Fenopron Reduced antihypertensive effect Details Timolol Flurbiprofen Ansaid Reduced antihypertensive effect Details Timolol Flurbiprofen Ophthalmic Ocufen Reduced antihypertensive effect Details Timolol Glimepiride Amaryl Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Timolol Glipizide Glucotrol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Timolol Glucagon Injection Baqsimi A transient increase in pulse and blood pressure Details Timolol Glucagon Injection / Solution Baqsimi A transient increase in pulse and blood pressure Details Timolol Glucagon Nasal Powder Baqsimi A transient increase in pulse and blood pressure Details Timolol Ibuprofen Addaprin Reduced antihypertensive effect Details Timolol Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Timolol Insulin Detemir (Rdna Origin) Injection Levemir Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Timolol Insulin Glulisine (Rdna Origin) Injection Apidra Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Timolol Ketoprofen Actron® Reduced antihypertensive effect Details Timolol Ketorolac Acular Reduced antihypertensive effect Details Timolol Ketorolac Injection Acular Reduced antihypertensive effect Details Timolol Ketorolac Nasal Spray Sprix Reduced antihypertensive effect Details Timolol Ketorolac Ophthalmic Acular Reduced antihypertensive effect Details Timolol Linagliptin Tradjenta Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Timolol Liraglutide Injection Saxenda Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Timolol Lixisenatide Injection Adlyxin® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details

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