Tobramycin

20 interactions
Also sold as: Bethkis Kitabis Tobi Tobrex

Read the full Tobramycin drug information page

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Aspirin Aspirin Rectal Furosemide Injection Cidofovir Injection Colistimethate Injection Cyclosporine Injection
10 Major 3 Moderate 7 Minor
All (20) Major (10) Moderate (3) Minor (7)

Major

Tobramycin Aspirin Acuprin® Increased aspirin exposure and an increased risk of nephrotoxicity Details Tobramycin Aspirin Rectal Aspirin Increased aspirin exposure and an increased risk of nephrotoxicity Details Tobramycin Cefepime Injection Maxipime® An increased risk of nephrotoxicity and an increased risk of ototoxicity Details Tobramycin Cidofovir Injection Vistide® Nephrotoxicity Details Tobramycin Colistimethate Injection Coly-Mycin M® Respiratory depression Details Tobramycin Cyclosporine Injection Atopica An increased risk of renal dysfunction or nephrotoxicity Details Tobramycin Cyclosporine Ophthalmic Cequa An increased risk of renal dysfunction or nephrotoxicity Details Tobramycin Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Tobramycin Foscarnet Injection Foscavir Nephrotoxicity Details Tobramycin Furosemide Injection Disal Increased tobramycin plasma and tissue concentrations and additive ototoxicity and/or nephrotoxicity Details

Moderate

Tobramycin Carboplatin Kyxata Ototoxicity Details Tobramycin Carboplatin Injection Kyxata Ototoxicity Details Tobramycin Cisplatin Injection Platinol-AQ® Renal dysfunction Details

Minor

Tobramycin Amoxicillin Amoxi Drop Loss of aminoglycoside efficacy Details Tobramycin Ampicillin Amcill® Loss of aminoglycoside efficacy Details Tobramycin Ampicillin Injection Omnipen-N® Loss of aminoglycoside efficacy Details Tobramycin Cefotaxime Injection Claforan Increased plasma phosphorus Details Tobramycin Nafcillin Injection Unipen® Injection Loss of aminoglycoside efficacy Details Tobramycin Penicillin G Procaine Injection Bactracillin G Loss of aminoglycoside efficacy Details Tobramycin Penicillin V Potassium Beepen-VK® Loss of aminoglycoside efficacy Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.