Tofacitinib

Name: Tofacitinib Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

9 interactions 1 explained in plain English

Also sold as: Xeljanz Xeljanz® Xeljanz® XR

About Tofacitinib

Tofacitinib is used alone or with other medications to treat rheumatoid arthritis (condition in which the body attacks its own joints causing pain, swelling, and loss of function) in adults who are unable to take or did not respond to one or more tumor necrosis factor (TNF) inhibitor medication(s). It is also used to t… Read the full Tofacitinib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abatacept Injection Anifrolumab-Fnia Injection Azathioprine Abatacept Cyclosporine Injection Cyclosporine Ophthalmic

7 Major 2 Moderate

All (9) Major (7) Moderate (2)

Major

Tofacitinib Abatacept Injection Orencia An increased risk of infection Details Tofacitinib Anifrolumab-Fnia Injection Saphnelo Additive effects due to duplication of therapy Details Tofacitinib Azathioprine Azasan Increased risk of immunosuppression Details Tofacitinib Abatacept Orencia Explained An increased risk of infection Details Tofacitinib Cyclosporine Injection Atopica Increased risk of immunosuppression Details Tofacitinib Cyclosporine Ophthalmic Cequa Increased risk of immunosuppression Details Tofacitinib Letermovir Injection Prevymis Increased CYP3A substrate exposure Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.