Tolazamide

58 interactions 3 explained in plain English
Also sold as: Tolinase®
About Tolazamide

Tolazamide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Tolazamide is in a class of medications called sulfonylureas. Tolazamide lowers blo… Read the full Tolazamide drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ofloxacin Insulin Glulisine (Rdna Origin) Injection Orlistat Methotrexate Moxifloxacin Levofloxacin Injection
29 Major 29 Moderate
All (58) Major (29) Moderate (29)

Moderate

Tolazamide Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Tolazamide Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) An increased risk of hypoglycemia Details Tolazamide Enalapril Epaned An increased risk of hypoglycemia Details Tolazamide Esmolol Brevibloc Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolazamide Exenatide Injection Bydureon Increased risk of hypoglycemia Details Tolazamide Fosinopril Monopril® An increased risk of hypoglycemia Details Tolazamide Labetalol Normodyne® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolazamide Levobunolol Ophthalmic AKBeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolazamide Levothyroxine Ermeza Worsening of glycemic control Details Tolazamide Linagliptin Tradjenta An increased risk of hypoglycemia Details Tolazamide Linezolid Injection Zyvox An increased risk of hypoglycemia Details Tolazamide Liraglutide Injection Saxenda An increased risk of hypoglycemia Details Tolazamide Metformin Fortamet® An increased risk of hypoglycemia Details Tolazamide Moexipril Univasc® An increased risk of hypoglycemia Details Tolazamide Nadolol Corgard Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolazamide Nebivolol Bystolic Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolazamide Penbutolol Levatol® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolazamide Perindopril Aceon An increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.