Tolazamide

58 interactions 3 explained in plain English

Also sold as: Tolinase®

About Tolazamide

Tolazamide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Tolazamide is in a class of medications called sulfonylureas. Tolazamide lowers blo… Read the full Tolazamide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ofloxacin Insulin Glulisine (Rdna Origin) Injection Orlistat Methotrexate Moxifloxacin Levofloxacin Injection

29 Major 29 Moderate

All (58) Major (29) Moderate (29)

Major

Tolazamide Acarbose Prandase® Explained An increased risk of hypoglycemia Details Tolazamide Abiraterone Abirtega An increased risk of severe hypoglycemia Details Tolazamide Chloroquine Aralen® Hypoglycemia Details Tolazamide Delafloxacin Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolazamide Delafloxacin Injection Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolazamide Disopyramide Norpace Increased risk of hypoglycemia Details Tolazamide Dulaglutide Injection Trulicity Increased risk of hypoglycemia Details Tolazamide Furosemide Injection Disal An increased risk of hyperglycemia and an increased insulin requirement Details Tolazamide Gatifloxacin Ophthalmic Zymar® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolazamide Gemifloxacin Factive Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolazamide Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Tolazamide Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Tolazamide Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Tolazamide Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia Details Tolazamide Lanreotide Injection Somatuline An increased risk of hypoglycemia and impaired glucose regulation Details Tolazamide Levofloxacin Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolazamide Levofloxacin Injection Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolazamide Lixisenatide Injection Adlyxin® Increased risk of hypoglycemia Details Tolazamide Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tolazamide Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tolazamide Moxifloxacin Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolazamide Moxifloxacin Injection Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolazamide Moxifloxacin Ophthalmic Moxeza® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolazamide Octreotide Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Tolazamide Octreotide Injection Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Tolazamide Ofloxacin Floxin® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolazamide Ofloxacin Ophthalmic Ocuflox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolazamide Ofloxacin Otic Floxin® Otic Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolazamide Orlistat Alli An increased risk of hypoglycemia Details

Moderate

Tolazamide Lisinopril Prinivil Explained An increased risk of hypoglycemia Details Tolazamide Aspirin Acuprin® Increased risk of hypoglycemia Details Tolazamide Aspirin Rectal Aspirin Increased risk of hypoglycemia Details Tolazamide Atenolol Tenormin Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolazamide Acebutolol Sectral® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolazamide Benazepril Lotensin An increased risk of hypoglycemia Details Tolazamide Alogliptin Nesina An increased risk of hypoglycemia Details Tolazamide Betaxolol Betoptic S Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolazamide Betaxolol Ophthalmic Betoptic® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolazamide Bisoprolol Zebeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolazamide Captopril Capoten® An increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.