Tolvaptan

Name: Tolvaptan Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

44 interactions 5 explained in plain English

Also sold as: Jynarque Samsca

Read the full Tolvaptan drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colchicine Ketoconazole Topical Capmatinib Methotrexate Injection Mitapivat Lenacapavir Injection

2 Contraindicated 38 Major 4 Moderate

All (44) Contraindicated (2) Major (38) Moderate (4)

Moderate

Tolvaptan Trospium / Xanomeline Cobenfy Explained Increased oral sensitive CYP3A4 substrate that are P-gp substrates with NTI exposure and an increased risk on severity and frequen... Details Tolvaptan Dofetilide Tikosyn Increased dofetilide exposure Details Tolvaptan Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Tolvaptan Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.