Tramadol

167 interactions 8 explained in plain English
Also sold as: ConZip Qdolo Ultram
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Tramadol Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Tramadol Amitriptyline Elavil Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of serotonin syndr... Details Tramadol Sertraline Explained Increased traMADol exposure and reduced exposure of the active metabolite M1, increased risk for serotonin syndrome Details Tramadol Buprenorphine Belbuca Explained Reduced efficacy of traMADol, an increased risk of withdrawal symptoms, an increased risk of serotonin syndrome and an increased r... Details Tramadol Relugolix Orgovyx Explained Reduced traMADol exposure and reduced efficacy of traMADol Details Tramadol Dupilumab Injection Dupixent Explained Increased traMADol exposure and reduced exposure of the active metabolite Details Tramadol Trospium / Xanomeline Cobenfy Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of seizure Details Tramadol Acyclovir Avaclyr An increased risk of seizure Details Tramadol Acyclovir Injection Avaclyr An increased risk of seizure Details Tramadol Acyclovir Ophthalmic Avaclyr An increased risk of seizure Details Tramadol Acyclovir Topical Zovirax An increased risk of seizure Details Tramadol Alcaftadine Ophthalmic Lastacaft An increased risk of seizure Details Tramadol Ampicillin Amcill® An increased risk of seizure Details Tramadol Ampicillin Injection Omnipen-N® An increased risk of seizure Details Tramadol Aripiprazole Injection Abilify Increased risk of CNS depression Details Tramadol Asciminib Scemblix Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Asenapine Transdermal Patch Secuado Increased traMADol exposure, reduced exposure of the active metabolite and an increased risk of CNS depression Details Tramadol Atovaquone Mepron An increased risk of seizure Details Tramadol Azathioprine Azasan An increased risk of hepatotoxicity Details Tramadol Azithromycin AzaSite Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Aztreonam Injection Azactam An increased risk of seizure Details Tramadol Belumosudil Rezurock Explained Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Bicalutamide Casodex Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Atorvastatin Atorvaliq Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Abiraterone Abirtega Increased traMADol exposure and reduced exposure of the active metabolite Details Tramadol Aclidinium Oral Inhalation Tudorza Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of seizure Details Tramadol Alogliptin Nesina Increased traMADol exposure and reduced exposure of the active metabolite Details Tramadol Amlodipine Amvaz® Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Amphotericin B Injection Abelcet An increased risk of seizure Details Tramadol Azelastine Nasal Spray Astelin® Nasal Spray An increased risk of seizure Details Tramadol Azelastine Ophthalmic Optivar® An increased risk of seizure Details Tramadol Atropine Ophthalmic Atropine Care 1% Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of seizure Details Tramadol Besifloxacin Ophthalmic Besivance An increased risk of seizure Details Tramadol Bepotastine Ophthalmic Bepreve An increased risk of seizure Details Tramadol Bexarotene Targretin Reduced traMADol exposure and reduced efficacy of traMADol Details Tramadol Bexarotene Topical Targretin Reduced traMADol exposure and reduced efficacy of traMADol Details Tramadol Brigatinib Alunbrig Reduced traMADol exposure and reduced efficacy of traMADol Details Tramadol Brivaracetam Briviact Reduced traMADol exposure and reduced efficacy of traMADol Details Tramadol Brivaracetam Injection Briviact Reduced traMADol exposure and reduced efficacy of traMADol Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.