Tramadol

167 interactions 8 explained in plain English
Also sold as: ConZip Qdolo Ultram
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Tramadol Busulfan Injection Busulfex An increased risk of seizure Details Tramadol Butorphanol Injection Butorphic Reduced efficacy of traMADol, an increased risk of withdrawal symptoms, an increased risk of serotonin syndrome and an increased r... Details Tramadol Butorphanol Nasal Spray Stadol® NS Reduced efficacy of traMADol, an increased risk of withdrawal symptoms, an increased risk of serotonin syndrome and an increased r... Details Tramadol Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Tramadol Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Tramadol Chlorambucil Leukeran An increased risk of seizure Details Tramadol Chloroquine Aralen® Increased traMADol exposure, reduced exposure of the active metabolite and an increased risk of seizure Details Tramadol Clopidogrel Plavix Reduced efficacy of clopidogrel Details Tramadol Clotrimazole Aardora Anti-Fungal Maximum Strength Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Clotrimazole Lozenge Mycelex® Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Clotrimazole Topical Cruex Antifungal Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Clotrimazole Vaginal Gyne-Lotrimin 3® Cream Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Cyclopentolate Ophthalmic Akpentolate® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of seizure Details Tramadol Cyclosporine Injection Atopica Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Cyclosporine Ophthalmic Cequa Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Dacomitinib Vizimpro Increased traMADol exposure and reduced exposure of the active metabolite Details Tramadol Dalfampridine Ampyra An increased risk of seizure Details Tramadol Darolutamide Nubeqa Reduced traMADol exposure and reduced efficacy of traMADol Details Tramadol Dexamethasone Injection Decadron Reduced traMADol exposure and reduced efficacy of traMADol Details Tramadol Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced traMADol exposure and reduced efficacy of traMADol Details Tramadol Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Tramadol Diazepam Rectal Diastat Increased risk of CNS depression Details Tramadol Digoxin Cardoxin® Increased risk of digoxin toxicity Details Tramadol Diphenhydramine Injection Banophen Increased risk of urinary retention and/or severe constipation leading to paralytic ileus, an increased risk of seizure, an increa... Details Tramadol Diphenhydramine Topical Afterbite with Antihistamine Increased risk of urinary retention and/or severe constipation leading to paralytic ileus, an increased risk of seizure, an increa... Details Tramadol Dolasetron Anzemet Increased risk of serotonin syndrome Details Tramadol Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Tramadol Dronabinol Marinol Increased traMADol exposure and reduced exposure of the active metabolite Details Tramadol Enasidenib Idhifa Altered (reduced /increased) traMADol exposure, reduced efficacy of traMADol and reduced exposure of the active metabolite Details Tramadol Encorafenib Braftovi Reduced traMADol exposure and reduced efficacy of traMADol Details Tramadol Entrectinib Rozlytrek Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Epinastine Ophthalmic Elestat® An increased risk of seizure Details Tramadol Erdafitinib Balversa Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Esketamine Nasal Spray Spravato Increased traMADol exposure, an increased risk of CNS depression and an increased risk of seizures, serotonin syndrome and opioid... Details Tramadol Esomeprazole Nexium Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Esomeprazole Injection Nexium Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Estradiol Delestrogen Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Estradiol Topical Divigel Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Estradiol Transdermal Patch Alora® Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Estramustine Emcyt An increased risk of seizure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.