Tramadol

167 interactions 8 explained in plain English
Also sold as: ConZip Qdolo Ultram
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Tramadol Etomidate An increased risk of seizure Details Tramadol Everolimus Afinitor Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Febuxostat Uloric Increased traMADol exposure and reduced exposure of the active metabolite Details Tramadol Felodipine Plendil® Increased traMADol exposure and reduced exposure of the active metabolite Details Tramadol Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Tramadol Flecainide Tambocor® Increased traMADol exposure and reduced exposure of the active metabolite Details Tramadol Foscarnet Injection Foscavir An increased risk of seizure Details Tramadol Fostamatinib Tavalisse Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Furosemide Injection Disal Reduced efficacy of diuretics Details Tramadol Galantamine Razadyne An increased risk of seizure Details Tramadol Ganciclovir Cytovene® Oral An increased risk of seizure Details Tramadol Ganciclovir Injection Cytovene® I.V.® An increased risk of seizure Details Tramadol Ganciclovir Ophthalmic Zirgan An increased risk of seizure Details Tramadol Gatifloxacin Ophthalmic Zymar® An increased risk of seizure Details Tramadol Gefitinib Iressa Increased traMADol exposure and reduced exposure of the active metabolite Details Tramadol Glycopyrronium Topical Cuvposa® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Tramadol Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Tramadol Granisetron Injection Granisol Increased risk of serotonin syndrome Details Tramadol Hydralazine Apresoline® Increased traMADol exposure and reduced exposure of the active metabolite Details Tramadol Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Tramadol Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Tramadol Hydroxychloroquine Plaquenil Increased traMADol exposure, reduced exposure of the active metabolite and an increased risk of seizure Details Tramadol Ibrexafungerp Brexafemme Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Ifosfamide Injection Ifex An increased risk of seizure Details Tramadol Ipratropium Nasal Spray Atrovent Nasal Spray® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Tramadol Ipratropium Oral Inhalation Atrovent® HFA Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Tramadol Istradefylline Nourianz Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Ketoconazole Topical Extina® Foam Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Ketotifen Alaway An increased risk of seizure Details Tramadol Ketotifen Ophthalmic Alaway An increased risk of seizure Details Tramadol Labetalol Normodyne® Increased traMADol exposure and reduced exposure of the active metabolite Details Tramadol Lacosamide Injection Motpoly An increased risk of CNS depression Details Tramadol Lefamulin Xenleta Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Lenacapavir Injection Sunlenca Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Lenacapavir Oral Sunlenca Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Letermovir Injection Prevymis Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Tramadol Levofloxacin Levaquin An increased risk of seizure Details Tramadol Levofloxacin Injection Levaquin An increased risk of seizure Details Tramadol Levonorgestrel After banger Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.