Tramadol
167 interactions 8 explained in plain English
Also sold as:
ConZip
Qdolo
Ultram
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
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Major
Tramadol Levonorgestrel Intrauterine System Kyleena Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Linagliptin Tradjenta Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Lindane Gamene® An increased risk of seizure Details Tramadol Lithium Carbonate Lithobid Increased risk of serotonin syndrome and an increased risk of seizure Details Tramadol Lumateperone Caplyta Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Lurasidone Latuda Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Maprotiline Ludiomil® An increased risk of seizure Details Tramadol Medroxyprogesterone Amen® Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Medroxyprogesterone Injection Depo-Provera Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Tramadol Mefenamic Acid Ponstel® An increased risk of seizure Details Tramadol Mefloquine Lariam® An increased risk of seizure Details Tramadol Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Tramadol Meropenem An increased risk of seizure Details Tramadol Meropenem Injection Merrem® An increased risk of seizure Details Tramadol Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tramadol Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tramadol Methylphenidate Adhansia XR® An increased risk of seizure Details Tramadol Methylphenidate Transdermal Patch Daytrana An increased risk of seizure Details Tramadol Metoclopramide Injection Gimoti Increased risk of CNS depression Details Tramadol Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Tramadol Metronidazole Flagyl An increased risk of seizure Details Tramadol Metronidazole Injection Flagyl An increased risk of seizure Details Tramadol Metronidazole Topical MetroCream® An increased risk of seizure Details Tramadol Metronidazole Vaginal MetroGel® Vaginal An increased risk of seizure Details Tramadol Midazolam Nasal Spray Nayzilam Increased risk of CNS depression Details Tramadol Midazolam Injection Nayzilam Increased risk of CNS depression Details Tramadol Mitapivat Aqvesme Reduced traMADol exposure and reduced efficacy of traMADol Details Tramadol Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Tramadol Moxifloxacin Avelox An increased risk of seizure Details Tramadol Moxifloxacin Injection Avelox An increased risk of seizure Details Tramadol Moxifloxacin Ophthalmic Moxeza® An increased risk of seizure Details Tramadol Nafcillin Injection Unipen® Injection Reduced traMADol exposure, reduced efficacy of traMADol and an increased risk of seizure Details Tramadol Nalbuphine Injection Nubain® Reduced efficacy of traMADol, an increased risk of withdrawal symptoms, an increased risk of serotonin syndrome and an increased r... Details Tramadol Neostigmine Methylsulfate Bloxiverz An increased risk of seizure Details Tramadol Nevirapine Viramune Reduced traMADol exposure and reduced efficacy of traMADol Details Tramadol Nicardipine Cardene Increased traMADol exposure and reduced exposure of the active metabolite Details Tramadol Ofloxacin Floxin® An increased risk of seizure Details Tramadol Ofloxacin Ophthalmic Ocuflox An increased risk of seizure Details Tramadol Ofloxacin Otic Floxin® Otic An increased risk of seizure Details Tramadol Olaparib Lynparza Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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