Tramadol

Name: Tramadol Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

167 interactions 8 explained in plain English

Also sold as: ConZip Qdolo Ultram

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Methotrexate Injection Lumateperone Hydromorphone Rectal Everolimus Mitapivat

1 Contraindicated 164 Major 2 Moderate

All (167) Contraindicated (1) Major (164) Moderate (2)

Major

Tramadol Olopatadine Pataday An increased risk of seizure Details Tramadol Olopatadine Nasal Spray PATANASE An increased risk of seizure Details Tramadol Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details Tramadol Penicillin V Potassium Beepen-VK® An increased risk of seizure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.