Trifluoperazine
50 interactions 3 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Metoclopramide Nasal Spray
Metoclopramide Injection
Cetirizine Ophthalmic
Hydromorphone Rectal
Arsenic Trioxide
Ofloxacin
Contraindicated
Trifluoperazine Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Trifluoperazine Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome DetailsMajor
Trifluoperazine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Trifluoperazine Amitriptyline Elavil Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Trifluoperazine Buprenorphine Belbuca Explained An increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Trifluoperazine Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Trifluoperazine Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Trifluoperazine Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation Details Trifluoperazine Azithromycin AzaSite An increased risk of QT interval prolongation Details Trifluoperazine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Trifluoperazine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Trifluoperazine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Trifluoperazine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Trifluoperazine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Trifluoperazine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Trifluoperazine Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Trifluoperazine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Trifluoperazine Diazepam Rectal Diastat Increased risk of CNS depression Details Trifluoperazine Disopyramide Norpace An increased risk of QT interval prolongation Details Trifluoperazine Dofetilide Tikosyn An increased risk of QT interval prolongation Details Trifluoperazine Dolasetron Anzemet Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Trifluoperazine Dolasetron Injection Anzemet Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Trifluoperazine Esketamine Nasal Spray Spravato Increased risk of sedation Details Trifluoperazine Fentanyl Transdermal Patch Duragesic® Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Trifluoperazine Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Trifluoperazine Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Trifluoperazine Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Trifluoperazine Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Trifluoperazine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Trifluoperazine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Trifluoperazine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Trifluoperazine Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Trifluoperazine Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Trifluoperazine Granisetron Injection Granisol An increased risk of QT interval prolongation Details Trifluoperazine Hydromorphone Injection Dilaudid Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Trifluoperazine Hydromorphone Rectal available generically Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Trifluoperazine Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Trifluoperazine Lacosamide Injection Motpoly An increased risk of CNS depression Details Trifluoperazine Levodopa Oral Inhalation Inbrija Reduce efficacy of levodopa (foslevodopa), an increased risk of exacerbating psychosis [or symptoms of Parkinson's disease: delusi... Details Trifluoperazine Lithium Carbonate Lithobid Weakness, dyskinesias, increased extrapyramidal symptoms, encephalopathy, and brain damage DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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