Vadadustat

19 interactions 1 explained in plain English

Also sold as: Vafseo

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Simvastatin Acyclovir Acyclovir Injection Oseltamivir Irinotecan Injection Methotrexate Injection

19 Major

All (19) Major (19)

Major

Vadadustat Simvastatin Flolipid Explained Increased simvastatin exposure and an increased risk of simvastatin-related adverse effects Details Vadadustat Acyclovir Avaclyr Increased OAT3 substrate exposure and an increased risk of OAT3 substrate-related adverse effect Details Vadadustat Acyclovir Injection Avaclyr Increased OAT3 substrate exposure and an increased risk of OAT3 substrate-related adverse effect Details Vadadustat Acyclovir Ophthalmic Avaclyr Increased OAT3 substrate exposure and an increased risk of OAT3 substrate-related adverse effect Details Vadadustat Acyclovir Topical Zovirax Increased OAT3 substrate exposure and an increased risk of OAT3 substrate-related adverse effect Details Vadadustat Alpelisib Piqray Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Vadadustat Aztreonam Injection Azactam Increased risk of aztreonam exposure Details Vadadustat Baricitinib Olumiant Increased OAT3 substrate exposure and an increased risk of OAT3 substrate-related adverse effect Details Vadadustat Cefaclor Ceclor® Increased cefaclor exposure and an increased risk of cefaclor-related adverse effect Details Vadadustat Famotidine Calmicid Increased famotidine exposure and an increased risk of famotidine-related adverse effect Details Vadadustat Famotidine Injection Calmicid Increased famotidine exposure and an increased risk of famotidine-related adverse effect Details Vadadustat Furosemide Injection Disal Increased OAT3 substrate exposure and an increased risk of OAT3 substrate-related adverse effect Details Vadadustat Gemfibrozil Lopid Increased vadadustat exposure and an increased risk of vadadustat-related adverse effects Details Vadadustat Irinotecan Camptosar Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effect Details Vadadustat Irinotecan Injection Camptosar Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effect Details Vadadustat Lanthanum Fosrenol® Reduced vadadustat exposure and reduced efficacy of vadadustat Details Vadadustat Methotrexate Jylamvo Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effect Details Vadadustat Methotrexate Injection Abitrexate® Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effect Details Vadadustat Oseltamivir Tamiflu Increased oseltamivir carboxylate exposure and an increased risk of oseltamivir carboxylate-related adverse effect Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.